半岛bd体育手机客户端 介绍
靶标:
CACNA1A 半岛bd体育手机客户端 别名: APCA; BI; CACNL1A4; CAV2.1; DEE42; EA2; EIEE42; FHM; HPCA; MHP; MHP1; SCA6; CACNA1A; calcium voltage-gated channel subunit alpha1 A; calcium voltage-gated channel subunit alpha1 A; voltage-dependent P/Q-type calcium channel subunit alpha-1A; brain calcium channel 1; brain calcium channel I; calcium channel, L type, alpha-1 polypeptide; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit; voltage-gated calcium channel subunit alpha Cav2.1; 电压依赖性钙通道Cav2.1; 背景信息:
calcium voltage-gated channel subunit alpha1 A(CACNA1A) Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits
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