半岛bd体育手机客户端 介绍
靶标：
ATP6V0A1 半岛bd体育手机客户端 别名： ATP6N1； ATP6N1A； Stv1； VPP1； Vph1； a1； ATP6V0A1； ATPase H+ transporting V0 subunit a1； ATPase H+ transporting V0 subunit a1； V-type proton ATPase 116 kDa subunit a 1； ATPase, H+ transporting, lysosomal V0 subunit a1； ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)； H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1； V-ATPase 116 kDa subunit a 1； V-ATPase 116 kDa subunit a1； V-ATPase subunit a1； V-type proton ATPase 116 kDa subunit a； V-type proton ATPase 116 kDa subunit a1； clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit； vacuolar adenosine triphosphatase subunit Ac116； vacuolar proton pump subunit 1； vacuolar proton translocating ATPase 116 kDa subunit A； vacuolar-type H(+)-ATPase 115 kDa subunit； 氢离子转运ATP合成酶A1； 背景信息：
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
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