Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-basedcereblon(CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to formPROTAC^[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

289.24

C₁₃H₁₁N₃O₅

1547162-41-3

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