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Ferric citrate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ferric citrate图片
CAS NO: 3522-50-7
包装与价格：
包装 价格(元)
100mg 电议
200mg 电议
500mg 电议

半岛bd体育手机客户端 名称
柠檬酸铁
Iron(III) citrate
Zerenex
半岛bd体育手机客户端 介绍
Ferric citrate (Iron(III) citrate)，一种具有口服活性的铁补充剂，是一种有效的磷酸盐结合剂。Ferric citrate 可用于缺铁性贫血和慢性肾病 (CKD)的研究。
生物活性

Ferric citrate (Iron(III) citrate), an orally active iron supplement, is an efficacious phosphate binder. Ferric citratee can be used for iron deficiency anemia and chronic kidney disease (CKD) research[1][2].
体外研究
(In Vitro)

Ferric citrate (Iron(III) citrate; 1 mM; 24 hours) significantly induces CM cell death[1].
Ferric citrate (Iron(III) citrate; 0.1 mM, 1 mM, 2 mM; 24 hours) increases ROS generation in cardiomyocyte (CM) cells in a dose-dependent manner[1].

Cell Viability Assay[1]

Cell Line: Cardiomyocyte (CM) cells
Concentration: 1 mM
Incubation Time: 24 hours
Result: Significantly induced CM cell death.
体内研究
(In Vivo)

Here we compared the effects of Ferric citrate (25 μg/g) administration versus a mineral sufficient control diet using the Col4a3 knockout mouse model of progressive CKD and age-matched wild-type mice. Ferric citrate is given to knockout mice for four weeks beginning at six weeks of age when they had overt chronic kidney disease (CKD), or for six weeks beginning at four weeks of age when they had early CKD. Ferric citrate rescues iron deficiency and anemia in knockout mice regardless of the timing of treatment initiation, and circulating levels and bone expression of FGF23 are reduced. Ferric citrate also improves cardiac function and significantly improves survival[3].
Ferric citrate is an efficacious and safe phosphate binder that increases iron stores and reduces intravenous iron and erythropoietin-stimulating agent use while maintaining hemoglobin. Ferric citrate can increase transferrin saturation, serum ferritin, and hemoglobin[2].
Clinical Trial
分子量

244.94
性状

Solid
Formula

C6H5FeO7
CAS 号

3522-50-7
中文名称

柠檬酸铁；枸橼酸铁；柠檬酸三铁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:

H2O : 5 mg/mL(20.41 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 4.0826 mL 20.4132 mL 40.8263 mL
5 mM 0.8165 mL 4.0826 mL 8.1653 mL
10 mM 0.4083 mL 2.0413 mL 4.0826 mL
*

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： PBS

    Solubility: 10 mg/mL (40.83 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

* 以上所有助溶剂都可在本网站选购。
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