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Isobavachalcone
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Isobavachalcone图片
CAS NO: 20784-50-3
包装与价格：
包装 价格(元)
10 mM * 1 mL in DMSO 电议
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议

半岛bd体育手机客户端 名称
补骨脂乙素
Corylifolinin
Isobacachalcone
半岛bd体育手机客户端 介绍
Isobavachalcone (Corylifolinin) 来源于补骨脂，是一种 Akt信号通路的有效抑制剂，可诱导人类癌细胞凋亡 (以 IC50值为 7.92 μM 抑制 OVCAR-8 癌细胞生长)，具有抗癌和抗增殖活性。Isobavachalcone 还能诱导 OVCAR-8 细胞中活性氧的产生。
生物活性

Isobavachalcone (Corylifolinin) is derived fromPsoralea corylifolia Linn.and is a potent inhibitor ofAktsignaling pathway, which inducesapoptosisin humancancercells (Inhibits OVCAR-8 cell growth with anIC50value of 7.92 μM). Isobavachalcone also inducesReactive Oxyen Species (ROS)generation in OVCAR-8 cells and has exhibitcanceranti-promotive and anti-proliferative activity[1].
IC50& Target

IC50: 7.92 μM (OVCAR-8 cell)[1]
体外研究
(In Vitro)

Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively[1].
Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation[1].
Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1].

Cell Proliferation Assay[1]

Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells
Concentration: 6.0-48.0 μM
Incubation Time: 72 hours
Result: Inhibited the proliferation of human cancer cells.

Western Blot Analysis[1]

Cell Line: OVCAR-8 or PC3 cells
Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
Incubation Time: 6 hours
Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: OVCAR-8 cells and PC3 cells
Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
Incubation Time: 72 hours
Result: Led to dose dependent increase of apoptosis.
体内研究
(In Vivo)

Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].

Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g)[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours
Result: Increased in blood glucose levels.
分子量

324.37
性状

Solid
Formula

C20H20O4
CAS 号

20784-50-3
中文名称

补骨脂乙素；补骨酯乙素；异补骨脂查耳酮；异补骨脂查尔酮
结构分类
  • Flavonoids
  • Chalcones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Psoralea corylifoliaL.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro:

DMSO : 11 mg/mL(33.91 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 3.0829 mL 15.4145 mL 30.8290 mL
5 mM 0.6166 mL 3.0829 mL 6.1658 mL
10 mM 0.3083 mL 1.5414 mL 3.0829 mL
*

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。
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