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Physostigmine hemisulfate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Physostigmine hemisulfate图片
CAS NO: 64-47-1
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
毒扁豆碱半硫酸盐
Eserine hemisulfate
半岛bd体育手机客户端 介绍
Physostigmine hemisulfate (Eserine hemisulfate) 是一种可逆的乙酰胆碱酯酶 ( AChE) 抑制剂。Physostigmine hemisulfate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine hemisulfate 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine hemisulfate 也是抗胆碱能中毒的解毒剂。
生物活性

Physostigmine hemisulfate (Eserine hemisulfate) is a reversibleacetylcholinesterase (AChE)inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning[1][2][3][4].
体内研究
(In Vivo)

Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4].

Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2]
Dosage: 0.03, 0.1, and 0.3 mg/kg
Administration: SC; daily for 6 weeks
Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Clinical Trial
分子量

324.38
Formula

C15H21N3O2.1/2H2O4S
CAS 号

64-47-1
中文名称

毒扁豆碱半硫酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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