您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> Ribavirin 5'-monophosphate(lithium salt)
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
Ribavirin 5'-monophosphate(lithium salt)
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ribavirin 5'-monophosphate(lithium salt)图片
CAS NO: 66983-94-6
包装与价格：
包装 价格(元)
500μg 电议
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
Cas No. 66983-94-6
别名 利巴韦林5'-单磷酸二锂盐
化学名 1-(5-O-phosphono-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, dilithium salt
Canonical SMILES O[C@@H]1[C@@H](COP([O-])([O-])=O)O[C@@H](N2N=C(C(N)=O)N=C2)[C@@H]1O.[Li+].[Li+]
分子式 C8H11N4O8P.2Li
分子量 336.1
溶解度 PBS (pH 7.2): 10 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述 Ribavirin 5'-monophosphate inhibits viral DNA and RNA replication in vitro via the strong competitive inhibition of inosine monophosphate dehydrogenase (IMPDH), with a reported Ki value of 270 nM, and thus inhibits guanosine triphosphate synthesis. This agent, a metabolite of the prodrug ribavirin , exhibits broad-spectrum antiviral activity, particularly against myxoviruses. The antiviral effects of ribavirin require conversion to the monophosphate form via adenosine kinase. The anti-HIV activity of ribavirin in cultured human lymphocytes, as well as the anti-influenza activity of this prodrug in MDCK cells, have been attributed to ribavirin 5'-monophosphate.
Baidu
map