Cas No. |
41692-24-4 |
化学名 |
9-oxo-15R-hydroxy-16,16-dimethyl-prosta-10,13E-dien-1-oic acid |
Canonical SMILES |
CCCCC(C)(C)C(O)\C=C\[C@H]1C=CC(=O)C1CCCCCCC(=O)O |
分子式 |
C22H36O4 |
分子量 |
364.5 |
溶解度 |
DMF: >75 mg/ml (from PGA1),DMSO: >50 mg/ml (from PGA1),Ethanol: >100 mg/ml (from PGA1),PBS pH 7.2: >2.4 mg/ml (from PGA1) |
储存条件 |
Store at -20°C |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
16,16-dimethyl PGA1 is a metabolism resistant analog of PGA1. In vitro, it inhibits the viral replication in both HSV and HIV-1 infection systems at concentrations that do not adversely alter cellular DNA synthesis. The ID50 for HSV-1 strains in Vero cells and human foreskin fibroblasts are 3.8-5.6 ug/ml and 4.6-7.3 ug/ml, respectively. The ID50 for T cells acutely infected with HIV-1 is 2.5 ug/ml. |