Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitiveNMDA receptorantagonist, inhibit CYP2B6 and CYP2D6 with K_iof 0.51 nM and 94.9 μM, respectively.

NMDA Receptor^[1].

Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type^[1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity^[2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC₅₀) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1^[3].

215.76

Solid

C₁₂H₂₂ClN

41100-52-1

盐酸美金刚

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : ≥ 33.33 mg/mL(154.48 mM)

*"≥" means soluble, but saturation unknown.

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。