CAS NO: | 71145-03-4 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 |
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644[1]. Bay K 8644 is aL-type Ca2+channelagonist with anEC50of 17.3 nM. Bay K 8644 increases Ca2+influx through sarcolemmal Ca2+channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects[2][3]. |
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IC50& Target[2] |
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体外研究 (In Vitro) |
In newborn rat ventricular cardiomyocytes, Bay K 8644 (1 μM) treatment increases L-type calcium current density in 2-day-old cells. The higher increase of L-type calcium current density by Bay K 8644 in 2-day- than in 7-day-old cultured cells could be interpreted as the result of a difference in the phosphorylation level of calcium channels for each stage of development[4].
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体内研究 (In Vivo) |
A one time dose as low as 10 μg/kg of Bay K 8644 significantly elevates mean arterial pressure (MAP) in endotoxin-treated hypotensive rats while having minimal effects in normal rats. Bay K 8644 also causes a dose-dependent decrease in heart rate of 37% in endotoxin-treated rats and 39% in control rats[5].
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分子量 |
356.30 |
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性状 |
Solid |
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Formula |
C16H15F3N2O4 |
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CAS 号 |
71145-03-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 83.33 mg/mL(233.88 mM;Need ultrasonic)
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In Vivo:
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