Vemurafenib-d5 (PLX4032-d5) is the deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor ofB-RAFkinase, withIC₅₀s of 31 and 48 nM forRAF^V600Eand c-RAF-1, respectively^[1][4]. Vemurafenib induces cellautophagy^[5].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

494.95

C₂₃H₁₃D₅ClF₂N₃O₃S

1365986-90-8

维罗非尼 d5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.