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STAT3-SH2 domain inhibitor 1
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STAT3-SH2 domain inhibitor 1图片
CAS NO: 2816059-41-1
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
STAT3-SH2 domain inhibitor 1 是一种有效的 Src 同源性 2 (SH2) STAT3结构域 ( STAT3-SH2 domain) 抑制剂，其 Kd值为1.57 μM。STAT3-SH2 domain inhibitor 1 可抑制 STAT3 信号转导和转录激活。STAT3-SH2 domain inhibitor 1 诱导胃癌细胞凋亡 ( apoptosis)。STAT3-SH2 domain inhibitor 1 可用于癌症的研究。
生物活性

STAT3-SH2 domain inhibitor 1 is a potentSrcHomology 2 (SH2) Domain ofSTAT3(STAT3-SH2 domain)inhibitor with aKdvalue of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibitsSTAT3signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 inducesapoptosisin gastriccancercells. STAT3-SH2 domain inhibitor 1 can be used in research ofcancer[1].
体外研究
(In Vitro)

STAT3-SH2 domain inhibitor 1 (compound 7; 1-5 μM; 24 h; AGS and MGC-803 cell lines) strongly and selectively inhibits the STAT3 signaling pathway[1].
STAT3-SH2 domain inhibitor 1 (0-10 μM; 72 h) has antiproliferative activity with IC50values of 1.54 and 4.73 μM for AGS and MGC-803 cells, respectively[1].
STAT3-SH2 domain inhibitor 1 (1 and 3 μM; 72 h; AGS and MGC-803 cell lines) induces apoptosis effects in gastric cancer cells[1].

Cell Viability Assay[1]

Cell Line: AGS and MGC-803 cell lines
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Suppressed cancer cell proliferation and growth.

Apoptosis Analysis[1]

Cell Line: AGS and MGC-803 cell lines
Concentration: 1 and 3 μM
Incubation Time: 72 hours
Result: Induced apoptosis in AGS cells in a concentration-dependent manner, resulting in apoptotic percentages of 13.0 and 26.7% at 1 and 3 μM, respectively.
Induced apoptosis of MGC-803 cells in a dose-dependent way, leading to apoptotic percentage of 11.2% at 5 μM.

Western Blot Analysis[1]

Cell Line: AGS and MGC-803 cell lines
Concentration: 1 and 3 μM
Incubation Time: 24 hours
Result: Inhibited STAT3 phosphorylation at Tyr705 in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HEK-293T cells
Concentration: 1, 3, and 5 μM
Incubation Time: 24 hours
Result: Disrupted STAT3 dimerization in HEK-293T cells.
体内研究
(In Vivo)

STAT3-SH2 domain inhibitor 1 (compound 7; 5 and 15 mg/kg; i.p.; daily, for 20 d) exhibits superior antitumor activity in BALB/c male nude mice with gastric tumor xenografts[1].

Animal Model: BALB/c male nude mice with gastric tumor xenografts[1]
Dosage: 5 and 15 mg/kg
Administration: Intraperitoneal injection; daily, for 20 days
Result: Suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition (TGI) of 65.14% at 5 mg/kg and 79.13% at 15 mg/kg, respectively.
分子量

610.40
Formula

C28H28BF5N2O5S
CAS 号

2816059-41-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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