MLN3126 is an orally active and potentCCR9antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht anIC₅₀value of 6.3 nM forcalcium influx^[1].

MLN3126 inhibits CCL25-induced calcium mobilization with an IC₅₀value of 6.3 nM in CCR9 expressing cells^[1].
MLN3126 inhibits the binding of biotinylated CCL25 to CCR9 with an IC₅₀of 14.2 nM^[1].

MLN3126 (2.5% w/w; p.o.) decreases colonic level of IFN-γ, largely produced by T cells^[1].
MLN3126 (0.05, 0.25 and 1% (w/w); p.o.) has the potential activity for alleviating inflammatory bowel disease (IBD)^[1].

446.90

Solid

C₂₁H₁₉ClN₂O₅S

628300-71-0

Room temperature in continental US; may vary elsewhere.

DMSO : 25 mg/mL(55.94 mM;ultrasonic and warming and heat to 60℃)

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