Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide iscannabinoid CB1/CB2 receptoragonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild typeanimalsand suppresses lifespan extension in a TOR pathway mutant^[1][2].

Eicosapentaenoyl ethanolamide (EPEA) induces cell death in both LNCaP and PC3 cells (IC₅₀=16.19 μM). EPEA (24 hours) did not result in any significant changes in the G₁, S or G₂phases of the cell cycle^[1].

345.52

C₂₂H₃₅NO₂

109001-03-8

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