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RU 24969 hemisuccinate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RU 24969 hemisuccinate图片
CAS NO: 66611-27-6
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
RU 24969 hemisuccinate 是一种优先的 5-HT1B激动剂， Ki值为 0.38 nM，对 5-HT1A受体也显示出明显的亲和力 ( Ki=2.5 nM)，对脑中其他受体部位的亲和力很低。RU 24969 hemisuccinate 可减少液体消耗并增加向前运动。
生物活性

RU 24969 hemisuccinate is a preferential5-HT1Bagonist, with aKiof 0.38 nM, but also displays appreciable affinity for the5-HT1Areceptor(Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].
IC50& Target[1]

5-HT1AReceptor

2.5 nM (Ki)

5-HT1BReceptor

0.38 nM (Ki)
体外研究
(In Vitro)

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].
体内研究
(In Vivo)

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
分子量

287.34
Formula

C14H16N2O.1/2C4H6O4
CAS 号

66611-27-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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