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PARP-2-IN-3
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PARP-2-IN-3图片
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
PARP-2-IN-3 (Compound 12) 是一种有效的 PARP-2抑制剂，其 IC50为 0.07 μM。 PARP-2-IN-3 诱导癌细胞凋亡 ( apoptosis) 和坏死。 PARP-2-IN-3 具有较好的预测药代动力学参数和口服生物利用度。
生物活性

PARP-2-IN-3 (Compound 12) is a potentPARP-2inhibitor with anIC50of 0.07 μM. PARP-2-IN-3 inducesapoptosisand necrosis incancercells. PARP-2-IN-3 shows appropriate predicted pharmacokinetic parameters and oral bioavailability[1].
IC50& Target[1]

PARP-2

0.07 μM (IC50)
体外研究
(In Vitro)

PARP-2-IN-3 (Compound 12) (24 h) shows cytotoxic activities with IC50s of 6.14±0.5 μM and 6.05±0.4 μM against MDA-MB-231 and MCF-7, respectively[1].
PARP-2-IN-3 (6.05 μM; 24 h) arrests cell cycle at G2/M phase, and induces apoptosis and necrosis in MCF-7 cells[1].
PARP-2-IN-3 fills the space inside the PARP-2 pocket in a manner similar toOlaparib(HY-10162)[1].

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 and MCF-7
Concentration:
Incubation Time: 24 h
Result: Displayed remarkable cytotoxic activities with IC50s of 6.14±0.5 μM and 6.05±0.4 μM against MDA-MB-231 and MCF-7, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7
Concentration: 6.05 μM
Incubation Time: 24 h
Result: The percentage of cells in pre-G1 phase increased from 1.85% to 33.47%, while in G2/M phase increased from 11.84% to 32.04%. The percentage of cells in S phase slightly decreased from 29.95% to 26.18% and in G0/G1 phase decreased from 58.21% to 41.78%.

Apoptosis Analysis[1]

Cell Line: MCF-7
Concentration: 6.05 μM
Incubation Time: 24 h
Result: Induced an early apoptotic effect 22.52% and late apoptotic effect 3.72% in comparison to the untreated negative control MCF-7 cells which induced an early and late apoptotic effect 0.37% and 0.33%, respectively.
分子量

385.84
Formula

C20H20ClN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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