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GSK269962A hydrochloride
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GSK269962A hydrochloride图片
CAS NO: 2095432-71-4
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
GSK 269962 hydrochloride
半岛bd体育手机客户端 介绍
GSK269962A hydrochloride (GSK 269962 hydrochloride) 是一种有效的 ROCK抑制剂，作用于重组人 ROCK1和 ROCK2， IC50分别为 1.6 和 4 nM。GSK269962A hydrochloride 具有抗炎和血管舒张作用。
生物活性

GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potentROCKinhibitor withIC50s of 1.6 and 4 nM for recombinant humanROCK1andROCK2respectively. GSK269962A hydrochloride has anti-inflammatory and vasodilatory activities[1].
IC50& Target[1]

ROCK1

1.6 nM (IC50)

ROCK2

4 nM (IC50)

RSK1

132 nM (IC50)

MSK1

49 nM (IC50)

AKT1

955 nM (IC50)

AKT2

1350 nM (IC50)

AKT3

1510 nM (IC50)

CDK2

3500 nM (IC50)

GSK3α

1260 nM (IC50)
体外研究
(In Vitro)

GSK269962A has an IC50of 1.6 nM toward recombinant human ROCK1. GSK269962A exhibits more than 30-fold selectivity against a panel of serine/threonine kinases[1].
GSK269962A induces vasorelaxation in preconstricted rat aorta with an IC50of 35 nM[1].
体内研究
(In Vivo)

GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial[1].

Animal Model: Male Sprague-Dawley rats (350-400g)[1]
Dosage: 0.3, 1, and 3 mg/kg
Administration: Oral gavage; 12 hours
Result: Induced a dose-dependent reduction in blood pressure.
分子量

607.06
Formula

C29H31ClN8O5
CAS 号

2095432-71-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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