您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> WF-536
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
WF-536
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WF-536图片
CAS NO: 539857-64-2
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
WF-536 是一种 Rho 相关卷曲螺旋蛋白激酶 (ROCK)抑制剂，具有口服活性。WF-536 具有肿瘤抗转移活性。WF-536 可用于癌症研究。
生物活性

WF-536 is an orally active inhibitor ofRho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research ofcancer[1].
体外研究
(In Vitro)

WF-536（1、3、10、30、100 μM）抑制 LLC 细胞的侵袭和迁移以及内皮细胞在 Matrigel 上的侵袭、迁移和毛细管样管的形成，在这两种细胞类型下均无细胞毒性或抗增殖作用[1]。

Cell Migration Assay[1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 6 h (tumor cells), 4 h (endothelial cells)
Result: Significantly inhibited LLC-cell migration, with inhibitory rates of 23% and 44% at 10 and 30 μM, respectively.

Cell Invasion Assay[1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 3, 10, 30 μM
Incubation Time: 18 h
Result: Showed significant and concentration-dependent inhibition of LLC-cell invasion.

Cell Proliferation Assay[1]

Cell Line: LLC cells, Human umbilical vein endothelial cells
Concentration: 1, 30, 100 μM
Incubation Time: 24, 48, 72, and 96 h
Result: Showed no significant effect at 1-30 μM on the proliferation up to 96 h incubation, although the proliferation was decreased at 100 μM over 48 h.
体内研究
(In Vivo)

WF-536（口服；0.3-3 mg/kg/天；持续 28 天）抑制小鼠 Lewis 肺癌 (LLC) 转移和 LLC 诱导的血管生成[1]。

Animal Model: C57BL/6 mice (male, 6-week old)[1]
Dosage: 0.3, 1, 3 mg/kg
Administration: Oral; daily; for 28 days
Result: Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).
分子量

277.75
Formula

C14H16ClN3O
CAS 号

539857-64-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Baidu
map