JG-98 - 半岛电竞官方网址

立即咨询

咨询类型：

采购售后

*姓名：

*电话：

*单位：

Email：

*留言内容：

请详细说明您的需求。

*验证码：

JG-98

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1456551-16-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议

半岛bd体育手机客户端介绍

JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。JG-98 影响癌细胞和肿瘤相关巨噬细胞，显示抗癌活性。

生物活性

JG-98, an allostericheat shock protein70 (Hsp70)inhibitor, which binds tightly to a conserved site onHsp70and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting bothcancercells and tumor-associated macrophages^[1]^[2]^[3].

IC₅₀& Target

Heat shock protein 70^[1]

体外研究
(In Vitro)

JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC₅₀s between ~0.3 and 4 μM^[2].
JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells^[1].
JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27^[2].

Cell Proliferation Assay^[2]

Cell Line:	MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
Concentration:	30 nM-30 μM
Incubation Time:	72 hours
Result:	Active against all of the lines tested, and the EC₅₀s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	10 μM
Incubation Time:	48 hours
Result:	Incudes apoptotic mediators cleavage of caspase 3 and PARP.

体内研究
(In Vivo)

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells^[2].

Animal Model:	6-week-old NCR mice (xenografts of MCF7 and HeLa cells)^[2]
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; on days 0, 2, and 4
Result:	Limited tumor growth, but somewhat less effectively.

分子量

534.54

性状

Solid

Formula

C₂₄H₂₁Cl₂N₃OS₃

CAS 号

1456551-16-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 5 mg/mL(9.35 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.8708 mL	9.3538 mL	18.7077 mL
5 mM	0.3742 mL	1.8708 mL	3.7415 mL
10 mM	---	---	---

请根据半岛bd体育手机客户端在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。