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HDAC6-IN-11
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
HDAC6-IN-11图片
CAS NO: 2409072-27-9
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
HDAC6-IN-11 (Compound 9) 是一种选择性的 HDAC6抑制剂， IC50为 20.7 nM，比对其他HDAC 异构体有超过 300 倍的选择性。HDAC6-IN-11 对癌细胞表现出抗增殖活性。
生物活性

HDAC6-IN-11 (Compound 9) is a selectiveHDAC6inhibitor with theIC50value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity overHDACother isoforms. HDAC6-IN-11 shows anti-proliferative activities againstcancercells[1].
IC50& Target

HDAC6

20.7 nM (IC50)

HDAC8

7750 nM (IC50)
体外研究
(In Vitro)

HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1].
HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1].

Cell Proliferation Assay[1]

Cell Line: A549 and HCT116 cells
Concentration: 0.44-6.68 μM
Incubation Time: 48 hours
Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively).

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM
Incubation Time: 48 hours
Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
分子量

336.34
Formula

C19H16N2O4
CAS 号

2409072-27-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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