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mTOR/HDAC6-IN-1
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
mTOR/HDAC6-IN-1图片
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
mTOR/HDAC6-IN-1 是一种有效的哺乳动物雷帕霉素 ( mTOR) 和组蛋白去乙酰酶 ( HDAC6) 的双重抑制剂 (mTOR 和 HDAC6 的 IC50s 分别为 133.7 nM 和 56 nM)。mTOR/HDAC6-IN-1 可诱导明显的细胞自噬 ( autophagy)、细胞凋亡 ( apoptosis)，以及抑制迁移。mTOR/HDAC6-IN-1 具有研究三阴性乳腺癌 (TNBC) 的潜力。
生物活性

mTOR/HDAC6-IN-1 is a potentmTORandHDAC6dual inhibitor (IC50s of 133.7 nM and 56 nM formTORandHDAC6, respectively). mTOR/HDAC6-IN-1 can induce significantautophagy,apoptosisand suppress migration. mTOR/HDAC6-IN-1 has potential to research Triple-negative breastcancer(TNBC)[1].
IC50& Target[1]

mTOR

133.7 nM (IC50)

HDAC6

56 nM (IC50)
体外研究
(In Vitro)

mTOR/HDAC6-IN-1 (compound 10g) (0-100 μM; 48 hours) has a medium anti-proliferation activity with IC50of 8.4 μM, 10.6 μM and 14.3 μM in MDA-MB-231, MDA-MB-436 and MDA-MB-468 cells at 48h[1].
mTOR/HDAC6-IN-1 (10 μM; 6 hours) can significantly improve the thermal stability of HDAC6 in MDA-MB-231 cells, which indicates that mTOR/HDAC6-IN-1 has a selective inhibitory effect on HDAC6[1].
mTOR/HDAC6-IN-1 (2.5, 5, 10 μM; 2 weeks) inhibits MDA-MB-231 cells form the clone[1].
mTOR/HDAC6-IN-1 (2.5, 5, 10 μM; 48 hours) induces obvious autophagy with the accumulation of LC3 puncta in MDA-MB-231 cells[1].
mTOR/HDAC6-IN-1 (5, 10, 20 μM) induces significant MDA-MB-231 apoptosis in a dose-dependent manner, also up-regulates the expression of Bax, down-regulates bcl-2, and promotes the cleavage of PARP and apoptotic executive protein caspase8 and caspase3[1].
mTOR/HDAC6-IN-1 (5, 10, 20 μM; 48 hours) inhibited MDA-MB-231 cells migration in a dose-dependent manner, and decreases the expression of MMP-2 as well as increases the expression of E-cadherin[1].

Cell Viability Assay

Cell Line: MDA-MB-231, MDA-MB-436 and MDA-MB-468 cells[1]
Concentration: 0, 20, 40, 60, 80 and 100 μM
Incubation Time: 48 hours
Result: Had a medium anti-proliferation activity with IC50of 8.4 μM, 10.6 μM and 14.3 μM in MDA-MB-231, MDA-MB-436 and MDA-MB-468 cells at 48h.

Apoptosis Analysis

Cell Line: MDA-MB-231[1]
Concentration: 5, 10, 20 μM
Incubation Time:
Result: Induced significant MDA-MB-231 apoptosis in a dose-dependent manner, also up-regulates the expression of Bax, down-regulates bcl-2, and promotes the cleavage of PARP and apoptotic executive protein caspase8 and caspase3.

Cell Autophagy Assay

Cell Line: MDA-MB-231[1]
Concentration: 2.5, 5, 10 μM
Incubation Time: 48 hours
Result: Induced obvious autophagy with the accumulation of LC3 puncta in MDA-MB-231 cells
分子量

397.86
Formula

C20H20ClN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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