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BI-409306
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
BI-409306图片
CAS NO: 1189767-28-9
包装与价格：
包装 价格(元)
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议

半岛bd体育手机客户端 介绍
BI-409306 (BI-409306) 是一种有效的选择性 PDE9A 抑制剂，IC50 为 52 nM，对其他 PDE 活性较弱，例如 PDE1A (IC50, 1.4 ?M), PDE1C (IC50, 1.0 μ M); M)、PDE2A、PDE3A、PDE4B、PDE5A、PDE6AB、PDE7A 和 PDE10A（IC50 均 >10 μ；M）； BI-409306 可用于研究中枢神经系统疾病的记忆增强。
Cas No. 1189767-28-9
别名 BI-409306
Canonical SMILES O=C1C2=C(N(C3CCOCC3)N=C2)NC(CC4=CC=CC=N4)=N1
分子式 C16H17N5O2
分子量 311.34
溶解度 DMSO : ≥ 75 mg/mL (240.89 mM)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all >10 uM); BI-409306 can be used in the research of memory enhancement in CNS disorders.

BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 uM), PDE1C (IC50, 1.0 uM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all >10 uM), and has no obvious effect on 95 non-PDE targets at 10 uM. BI-409306 enhances long-term potentiation (LTP) in rat hippocampal slices[1].

References:
[1]. Cornelia Dorner-Ciossek, et al. BI 409306, a novel phosphodiesterase 9A inhibitor, part I: potency, selectivity and in-vitro functional characterization on synaptic plasticity. International Congress on Schizophrenia Research.
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