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Tosufloxacin
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tosufloxacin图片
CAS NO: 100490-36-6
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
A-61827
半岛bd体育手机客户端 介绍
Tosufloxacin (A-61827) 是一种具有口服活性的氟喹诺酮类抗生素。Tosufloxacin 对革兰氏阳性和革兰氏阴性细菌表现出广泛的抗菌活性。
生物活性

Tosufloxacin (A-61827) is an orally active fluoroquinoloneantibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].
IC50& Target

Quinolone
体外研究
(In Vitro)

Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities againstS. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens[2].

Cell Viability Assay[2]

Cell Line: S. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens
Concentration: 0.05-3.13 μg/mL
Incubation Time: 18 hours
Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL forS. aureus,Staphylococcus epidermidis,streptococci, andenterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL forBacteroides fragilis,Clostridium difficile, andClostridium perfringens, respectively.
体内研究
(In Vivo)

Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity againstS. aureus,E. coli, andP. aeruginosain vivo[2].

Animal Model: Male Slc:ICR mice infected withS. aureus[2]
Dosage: 1.27-2.15 mg/kg
Administration: Oral gavage; 1.27-2.15 mg/kg; once
Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected withE. coli[2]
Dosage: 0.16-0.30 mg/kg
Administration: Oral gavage; 0.16-0.30 mg/kg; once
Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL.
Animal Model: Male Slc:ICR mice infected withP. aeruginosa[2]
Dosage: 7.66-13.39 mg/kg
Administration: Oral gavage; 7.66-13.39 mg/kg; once
Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL.
分子量

404.34
Formula

C19H15F3N4O3
CAS 号

100490-36-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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