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Hydroxy-PEG4-acid

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

937188-59-5

包装与价格：

半岛bd体育手机客户端介绍

Hydroxy-PEG4-acid 是一种不可降解 (non-cleavable) 的含 4 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。Hydroxy-PEG4-acid 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。

Cas No.	937188-59-5
分子式	C₁₁H₂₂O₇
分子量	266.29
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Hydroxy-PEG4-acid is a non-cleavable 4 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs^[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].