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AR453588 hydrochloride
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AR453588 hydrochloride图片
CAS NO: 1065606-97-4
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
AR453588 hydrochloride 是一种有效的口服生物利用的抗糖尿病葡萄糖激酶 (glucokinase)激活剂， EC50为 42 nM。AR453588 hydrochloride 具有降血糖作用。
生物活性

AR453588 hydrochloride is a potent and orally bioavailable anti-diabeticglucokinase activator, with anEC50of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity[1].
体内研究
(In Vivo)

AR453588 hydrochloride (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice[1].
AR453588 hydrochloride (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14 day ob/ob mouse[1].
AR453588 hydrochloride (10 mg/kg; p.o.) treatment shows that the Tmax, AUCinf, Vss, CmaxandFare 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively[1].
AR453588 hydrochloride (1 mg/kg; i.v.) treatment shows that the CL, AUCinf, Vss, and t1/2are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively[1].

Animal Model: Male diabetic ob/ob mice[1]
Dosage: 3, 10, 30 mg/kg
Administration: Orally once-daily for 14 days
Result: Lowered the fasted blood glucose from the control animals on day 14 as well as the AUC of the OGTT (oral glucose tolerance tests).
Animal Model: Male CD-1 mice[1]
Dosage: 10 mg/kg
Administration: p.o. (Pharmacokinetic Analysis)
Result: The Tmax, AUCinf, Vss, CmaxandFwere 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively
分子量

556.10
Formula

C25H26ClN7O2S2
CAS 号

1065606-97-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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