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Lonodelestat
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lonodelestat图片
CAS NO: 906547-89-5
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
POL6014
半岛bd体育手机客户端 介绍
Lonodelestat (POL6014) 是有效的、具有口服活性的、选择性的人中性粒细胞弹性蛋白酶 (hNE)的肽类抑制剂。Lonodelestat (POL6014) 具有囊性纤维化 (CF) 研究的潜力 。
生物活性

Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor ofhuman neutrophilelastase(hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF)[1][2][3].
体内研究
(In Vivo)

Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice[1].
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001)[1].

Animal Model: Ten-week-old male C57BL/6j mice[1].
Dosage: 0.05, 0.2, 0.5 and 5 mg/kg.
Administration: Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.).
Result: Reduced the inflammatory processes of ALI in HNE treated mice.
Clinical Trial
分子量

1478.73
Formula

C71H111N15O19
CAS 号

906547-89-5
Sequence Shortening

cyclo[ASIPPQKYPPNle(bu)ET]
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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