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URAT1 inhibitor 3
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
URAT1 inhibitor 3图片
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
URAT1 inhibitor 3 是一种口服有效的选择性 URAT1抑制剂，其 IC50值为 0.8 nM。URAT1 inhibitor 3 具有降低尿酸的作用。URAT1 inhibitor 3 可用于痛风和高尿酸血症的研究。
生物活性

URAT1 inhibitor3 is a potent, orally active, selectiveURAT1inhibitor with anIC50value of 0.8 nM.URAT1 inhibitor3 has urate-lowering efficacy.URAT1 inhibitor3 can be used in research of gout and hyperuricemi[1].
IC50& Target

IC50: 0.8 nM (URAT1)[1]
体外研究
(In Vitro)

URAT1 inhibitor 3 (0-400 μM; 24 and 72 h; HepG2 and HK2 cells) has low toxicity and inhibits cell viability at high concentrations[1].
URAT1 inhibitor 3 (0.01-100 μM) has lower inhibition on urate excretion transporters with IC50values of 10.16 μM and 4.04 μM of OAT1 and ABCG2, respectively[1].

Cell Viability Assay[1]

Cell Line: HepG2 and HK2 cells
Concentration: 0, 100, 200, 300, and 400 μM
Incubation Time: 24 and 72 hours
Result: Had little cytotoxicity at 24 h and inhibition rate of 34.75% and 35.9% of HepG2 and HK2 cells, respectively.
体内研究
(In Vivo)

URAT1 inhibitor 3 (1-4 mg/kg; i.g.; once) has urate lowering efficacy in a mouse model of hyperuricemia[1].
URAT1 inhibitor 3 (50 mg/kg; i.g.; daily, for 14 d) has no hepatic and renal toxicities in mice[1].
URAT1 inhibitor 3 (50 mg/kg; i.g.; once) induces GSH depletion in Kunming mice with hyperuricemia model[1].

Animal Model: Male Kunming (KM) mice with hyperuricemia model[1]
Dosage: 1, 2, and 4 mg/kg
Administration: Oral gavage; once
Result: Decreased the serum urate levels in a dose-dependent manner.
Animal Model: Male Kunming mice[1]
Dosage: 50 mg/kg
Administration: Oral gavage; daily, for 14 days
Result: Did not cause renal toxicity.
Animal Model: Male Kunming mice with hyperuricemia model[1]
Dosage: 50 mg/kg
Administration: Oral gavage; once
Result: Decreased the serum GSH levels from 42.23 μM to 20.39 μM.
分子量

307.13
Formula

C14H8Cl2N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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