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MRS4596
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MRS4596图片
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
MRS4596 是一种有效的选择性 P2X4 受体 ( P2X4 receptor) 拮抗剂，对人 P2X4 受体的 IC50为 1.38 μM。MRS4596 在缺血性脑卒中模型中具有神经保护和神经康复作用。MRS4596 可用于缺血性脑卒中研究。
生物活性

MRS4596 is a potent and selectiveP2X4 receptorantagonist with anIC50value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke[1].
IC50& Target

IC50: 1.38 μM (human P2X4 receptor)[1]
体内研究
(In Vivo)

MRS4719 (compound 22c; 5 mg/kg; 3 days continuous infusion with an Alzet minipump) has neuroprotective and learning- and memory-enhancing activities in a mouse middle cerebral artery occlusion (MCAO) model of ischemic stroke[1].

Animal Model: Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
Dosage: 5 mg/kg
Administration: 3 days continuous infusion with an Alzet minipump
Result: Decreased in total hemispheric infarct volume while effects were not significant on cortical or striatal infarct volume alone.
分子量

439.42
Formula

C21H14N5NaO3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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