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C3a Receptor Agonist
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C3a Receptor Agonist图片
CAS NO: 944997-60-8
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 介绍
Cas No. 944997-60-8
化学名 α-cyclohexyl-N-[1-[1-oxo-3-(3-pyridinyl)propyl]-4-piperidinyl]-benzeneacetamide
Canonical SMILES O=C(N1CCC(NC(C(C2CCCCC2)C3=CC=CC=C3)=O)CC1)CCC4=CC=CN=C4
分子式 C27H35N3O2
分子量 433.6
溶解度 30mg/mL in ethanol, 30mg/mL in DMSO, 30mg/mL in DMF
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Complement 3a (C3a) receptor agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway.[1] Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury. [2] C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.[3] [4]

Reference:
[1]. Klos, A., Wende, E., Wareham, K.J., et al. International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 65(1), 500-543 (2013).
[2]. Wu, M.C.L., Brennan, F.H., Lynch, J.P.L., et al. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc. Natl. Acad. Sci. USA 110923), 9439-9444 (2013).
[3]. Rahpaymai, Y., Hietala, M.A., Wilhelmsson, U., et al. Complement: A novel factor in basal and ischemia-induced neurogenesis. EMBO J. 25(6), 1364-1374 (2006).
[4]. Shinjyo, N., Stahlberg, A., Dragunow, M., et al. Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells 27(11), 2824-2832 (2009).
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