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KRN2

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

248260-75-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

半岛bd体育手机客户端介绍

KRN2 是选择性的 T 细胞激活核因子 ( NFAT5) 的抑制剂， IC₅₀值为 100 nM。KRN2 有潜力用于 NFAT5-介导的慢性关节炎的潜能。

生物活性

KRN2 is a selective inhibitor ofnuclear factor of activated T cells(NFAT5), with anIC₅₀of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis^[1].

IC₅₀& Target

IC50: 100 nM (NFAT5)^[1].

体外研究
(In Vitro)

KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions^[1].
KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) ofNfat5exon 1^[1].

体内研究
(In Vivo)

KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role^[1].
KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration^[1].

Animal Model:	8-week-old C57BL/6 mice injected intradermally with 2 mg of complete Freund's adjuvant^[1].
Dosage:	3 mg/kg.
Administration:	Peritoneally (i.p.) daily for 2 weeks.
Result:	Effective in suppressing AIA.

Animal Model:	8-week-old DBA/1Jmice immunized with bovine type II collagen^[1].
Dosage:	3 mg/kg.
Administration:	Peritoneally (i.p.) daily.
Result:	Effective in suppressing CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.

分子量

479.93

Formula

C₂₇H₂₃ClFNO₄

CAS 号

248260-75-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.