Levocabastine(hydrochloride) - 半岛电竞官方网址

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Levocabastine(hydrochloride)

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

79547-78-7

包装与价格：

半岛bd体育手机客户端介绍

Levocabastine (R 50547) hydrochloride 是一种有效的选择性组胺 H1 受体拮抗剂。

Cas No.	79547-78-7
别名	R 50547 hydrochloride
Canonical SMILES	FC(C=C1)=CC=C1[C@@](CC2)(C#N)CC[C@@H]2N(C[C@H]3C)CC[C@]3(C(O)=O)C4=CC=CC=C4.Cl
分子式	C₂₆H₂₉FN₂O₂? HCl
分子量	457
溶解度	PBS (pH 7.2): 0.33 mg/mL
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells. It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively. Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM.