五乙酰槲皮素能以较低的结合能和较好的稳定性与F-蛋白相互作用，阻断病毒粘附。
| Cas No. | 1064-06-8 |
| 别名 | Pentaacetylquercetin |
| Canonical SMILES | CC(OC1=CC=C(C2=C(OC(C)=O)C(C(C(OC(C)=O)=CC(OC(C)=O)=C3)=C3O2)=O)C=C1OC(C)=O)=O |
| 分子式 | C25H20O12 |
| 分子量 | 512.4 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH 7.2) (1:4): 1 mg/mL,Ethanol: 2 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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描述 | Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in vitro (IC50 = 3.74 μg/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 μg/ml). Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 μM) and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 μM. It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 μM, respectively). |
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