(S)-Bromoenol lactone - 半岛电竞官方网址

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(S)-Bromoenol lactone

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

478288-94-7

包装与价格：

半岛bd体育手机客户端介绍

(S)-Bromoenol lactone ((S)-BEL) 是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶 A2β (iPLA2β) 抑制剂，可抑制血管加压素诱导的培养的大鼠主动脉平滑肌 (A10) 释放花生四烯酸IC50 为 2 μM 的细胞。

Cas No.	478288-94-7
别名	(S)-BEL; (S,E)-Bromoenol lactone
Canonical SMILES	Br/C=C1\CC[C@H](C(=O)O\1)c1cccc2ccccc12
分子式	C₁₆H₁₃BrO₂
分子量	317.2
溶解度	DMF: 50 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): .05 mg/ml
储存条件	Store at -20°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 ?M. (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.