SU16f is a potent and selectivePDGFRβinhibitor withIC₅₀s of 10 nM, 140 nM, 2.29 μM forPDGFRβ, PDGFR1, PDGFR2, respectively^[1]. Neutralization ofPDGFRβreceptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastriccancercell proliferation and migration^[2].

SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation^[1].
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM^[1].

386.44

Solid

C₂₄H₂₂N₂O₃

251356-45-3

Room temperature in continental US; may vary elsewhere.

DMSO : 50 mg/mL(129.39 mM;Need ultrasonic)

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