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Xentuzumab
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO: 1417158-65-6
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议

半岛bd体育手机客户端 名称
BI 836845
Anti-Human IGF1 and IGF2 Recombinant Antibody
半岛bd体育手机客户端 介绍
Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) 是重组的人源化单克隆抗体，靶向 IGF 配体 IGF1和 IGF2。Xentuzumab 抑制 IGF1和 IGF2的生长促进信号，抑制 AKT的激活。
生物活性

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a humanized monoclonal antibody that targets IGF ligandsIGF1andIGF2. Xentuzumab inhibits both ofIGF1andIGF2growth-promoting signalling and suppressesAKTactivation[1].
IC50& Target

IGF1, IGF2[1]
体外研究
(In Vitro)

Xentuzumab (0.01-1 mM; 96 h) inhibits IGF type 1 receptor signaling and (0.1 μM; 48 h) AKT serine/threonine kinase (AKT) phosphorylation in VCaP, DuCaP, and MDA PCa 2b cell in a dose-dependent manner[1].
Xentuzumab (0.01-1 mM; 5-10 d) losses of antiproliferative activity against PTEN-null LNCaP or PC-3 cells when PTEN knockdown[1].
Xentuzumab (1 μM; 24-72 h) arrests cell cycle at sub-G1 phase and induces apoptosis in VCaP cells[1].

Western Blot Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 0.1 μM
Incubation Time: 24 h and 48 h
Result: Increased in cleaved caspase 3/7 and PARP.
Decreased the level of phosphorylation of FoxO3a (S253)/FoxO1 (T24).

Cell Cycle Analysis[1]

Cell Line: Prostate cancer VCaP cells
Concentration: 1 μM
Incubation Time: 24 h, 48 h, and 72 h
Result: Increased in cleaved caspase 3/7 and induces cell apoptosis.
Increased the sub-G1 cell population.
体内研究
(In Vivo)

Xentuzumab (200 mg/kg i.p., once weekly for 10 weeks) in inhibits tumor growth in LuCaP 96CR patient-derived xenograft model in mice[1].

Animal Model: Fox Chase CB17 severe combined immunodeficiency (SCID; CB17/lcr-Prkdc scid/lcrlcoCrl) male mice with LuCaP 96CR cell (s.c.)[1]
Dosage: 200 mg/kg
Administration: Intraperitoneal injection; once weekly for 10 weeks; sacrificed 6 hours after the last dose
Result: Resulted in significant reductions in tumor volume.
CAS 号

1417158-65-6
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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