SW157765 is a selective non-canonical glucose transporterGLUT8 (SLC2A8)inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs^[1][2].

SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner^[1].

331.32

Solid

C₁₉H₁₃N₃O₃

332063-87-3

Room temperature in continental US; may vary elsewhere.

DMSO : 25 mg/mL(75.46 mM;ultrasonic and warming and heat to 60℃)

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