SRI-37240 is a potentpremature termination codons(PTCs) inhibitor. SRI-37240 suppressesCFTRnonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restoreCFTRfunction in primary bronchial epithelial cells when combination with G418^[1].

Premature termination codons, CFTR^[1]

SRI-37240 (1, 3, 10 and 30 μM; 48 h) induces concentration-dependent increases in CFTR-dependent (Forskolin-stimulated and sensitive to the inhibitor CFTR_Inh-172) chloride conductance^[1].
SRI-37240 (10 μM; 72 h) significantly increases the amount of full-length, fully glycosylated form of CFTR protein, and the unprocessed, immature form of full-length CFTR protein in 16HBEge cells when co-treated with G418 (100 μM)^[1].
SRI-37240 (10 μM; 24 h) alters cellular translation termination at PTCs in HEK293T cells, also increases global densities of ribosomes at normal stop codons without affecting densities of ribosomes in 3-UTRs^[1].
SRI-37240 (10 μM; 72 h) restores CFTR function in primary bronchial epithelial cells when combination with G418^[1].

385.46

Solid

C₂₄H₂₃N₃O₂

883956-47-6

Room temperature in continental US; may vary elsewhere.

DMSO : 11.36 mg/mL(29.47 mM;ultrasonic and warming and heat to 60℃)

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