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Insulin detemir
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO: 169148-63-4
包装与价格：
包装 价格(元)
100U 电议
300U 电议

半岛bd体育手机客户端 介绍
Insulin Detemir 是一种人工胰岛素，具有控制血糖水平的作用。Insulin Detemir 通过激活 Akt和细胞外信号调节激酶 ( ERK) 依赖的-cat 和 CREB 信号通路，促进 Gcg 表达，从而刺激 GLP-1 的分泌。地特胰岛素可用于 2 型糖尿病的研究。
生物活性

InsulinDetemir is an artificialinsulin, shows effect on controlling blood sugar levels.InsulinDetemir stimulatesGLP-1secretion as a consequence of enhanced Gcg expression by a mechanism involving activation ofAkt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways.InsulinDetemir can be used for type 2 diabetes research[1][2].
体外研究
(In Vitro)

Insulin Detemir (d-INS) (100 nM; 0.5-4 h) increases Gcg mRNA expression in primary fetal rat intestinal cell (FRIC) cultures, and (100 nM; 5 min and 10 min) induces rapid phosphorylation of Akt, as well[1].
Insulin Detemir (100 nM; 5-120 min) increases β-catenin phosphorylation, its nuclear translocation, and enhances cAMP response element-binding protein (CREB) phosphorylation in a phosphatidylinositol 3-kinase and/or mitogen-activated protein kinase kinase/extracellular signal-regulated kinase-sensitive manner[1].

Western Blot Analysis[1]

Cell Line: GLUTag cells
Concentration: 100 nM
Incubation Time: 0, 5, 10, 30, 60, and 120 min
Result: Stimulated CREB, ERK1/2, Akt and its downstream glycogen synthase kinase (GSK)-3 phosphorylation at 5 min and 10 min.
体内研究
(In Vivo)

Insulin Detemir (d-INS) (5 IU/kg; i.p.; once daily; 2 weeks) demonstrates weight-sparing effects compared with other insulin formulations, and shows a intestinal tissues preference, potentially involving the activation of insulin/-catenin/CREB signaling pathways[1].

Animal Model: Obese type 2 diabeticdb/dbmice[1]
Dosage: 5 IU/kg
Administration: Intraperitoneal injection; once daily for 2 weeks
Result: Decreased body weight of the mice after 14-day daily injection of d-INS (5 IU/kg) significantly compared with those injected with the same dose of human Insulin or saline.
Induced rapid phosphorylation of protein kinase B (Akt) in the gut L cells of normal mice.
Clinical Trial
性状

Liquid
Formula

C267H402N64O76S6
CAS 号

169148-63-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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