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CCR6 antagonist 1
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CCR6 antagonist 1图片
CAS NO: 588674-64-0
包装与价格：
包装 价格(元)
10 mM * 1 mL in DMSO 电议
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议
200mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
CCR6 antagonist 1 是一种 CCR6拮抗剂，可抑制 CCL20/CCR6信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究，如炎症性肠病 (IBDs)。
生物活性

CCR6 antagonist1 is aCCR6antagonist that inhibits theCCL20/CCR6axis.CCR6 antagonist1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1].
IC50& Target[1]

CCR6
体外研究
(In Vitro)

CCR6 antagonist 1 (compound 1b, 50 μM, 3 h) blocks the CCL20-induced CD4+T cell migration[1].
CCR6 antagonist 1 (30 nM-300 μM, 20 min) inhibits miniGi recruitment to CCR6 induced by CCL20, and β-arrestin-1 recruitment to CCR6 and CCR5 by CCL20 and CCL5 (5 nM), respectively[1].

Cell Migration Assay[1]

Cell Line: CCL20 (500 ng/mL)-induced CCR6+CD4+T cell
Concentration: 0.5, 5, 50 μM
Incubation Time: 3 h
Result: Inhibited CCL20-induced cell migration at 50 μM.
体内研究
(In Vivo)

CCR6 antagonist 1 (compound 1b, 1 mg/kg, s.c., twice daily for 3 days) alleviates TNBS-induced inflammatory responses in mice[1].
CCR6 antagonist 1 (1 mg/kg, s.c., twice, before and after zymosan treatment) shows anti-inflammatory effects
in Zymosan-induced peritonitis mice[1].

Animal Model: Murine model of colitis (5 mg/mouse TNBS-induced)[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection (s.c.), twice daily for 3 days.
Result: Improved mice general conditions, attenuated macroscopic injury and counteracted neutrophils infiltration, both in the colon and in lungs.
Animal Model: Zymosan-induced peritonitis mice[1]
Dosage: 1 mg/kg
Administration: Subcutaneous injection (s.c.), twice, before and after zymosan treatment
Result: Significantly reduced the total protein content and myeloperoxidase activity in the peritoneal lavage.
分子量

319.28
性状

Solid
Formula

C17H12F3NO2
CAS 号

588674-64-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:

DMSO : ≥ 100 mg/mL(313.20 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 3.1320 mL 15.6602 mL 31.3205 mL
5 mM 0.6264 mL 3.1320 mL 6.2641 mL
10 mM 0.3132 mL 1.5660 mL 3.1320 mL
*

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。
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