AEEA-AEEA - 半岛电竞官方网址

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AEEA-AEEA

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

半岛bd体育手机客户端介绍

AEEA-AEEA 是可降解 (cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。AEEA-AEEA 也是一个基于 PEG 的 PROTAC linker，可用于合成 PROTAC。

Cas No.	1143516-05-5
分子式	C₁₂H₂₄N₂O₇
分子量	308.33
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端描述	AEEA-AEEA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). AEEA-AEEA is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]^[2]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].