CAS NO: | 442-51-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
生物活性 |
Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of5-HT2Aserotonin receptor, with anKiof 397 nM[1]. |
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IC50& Target[1][2] |
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体外研究 (In Vitro) |
Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50of 190 nM[2].Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3].
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体内研究 (In Vivo) |
It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4].
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Clinical Trial |
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分子量 |
212.25 |
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性状 |
Solid |
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Formula |
C13H12N2O |
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CAS 号 |
442-51-3 |
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中文名称 |
去氢骆驼蓬碱;肉叶芸香碱;哈尔明碱 |
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结构分类 |
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来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 30 mg/mL(141.34 mM) *"≥" means soluble, but saturation unknown.
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