您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> Etrolizumab
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
Etrolizumab
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO: 1044758-60-2
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议
50mg 电议

半岛bd体育手机客户端 名称
rhuMAb Beta7
RG7413
PRO145223
半岛bd体育手机客户端 介绍
Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗- β7整合素单克隆抗体。Etrolizuma b是针对 α4β7 和 αEβ7 整合素的 β7 亚基的特异性靶向药物。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。
生物活性

Etrolizumab (rhuMAb Beta7) is a gut-selective, anti-β7integrinmonoclonal antibody. Etrolizumab is specific targeting of the β7 subunit ofα4β7and αEβ7 integrins withKivalues of 18 nM and 1800 pM for Humanα4β7and Human αEβ7-293, respectively. Etrolizumab can be used in research of inflammatory bowel disease (IBD)[1][2].
IC50& Target[1]

α4β7

αEβ7
体外研究
(In Vitro)

Etrolizumab (rhuMAb Beta7) binds the β7 subunit of both α4β7 and αEβ7 integrins with high affinity, with Kdvalues of 18 nM, 1800 pM, 181 pM, 116 pM, 57 pM, 31.7 pM, and 25.7 pM for Human α4β7, Human αEβ7-293, Mouse α4β7-38C13, Human α4β7-293, Rabbit PBLs, Human PBLs, and Cyno PBLs, respectively[1].
Etrolizumab (RPMI 8866 cells and αEβ7-293 cells) blocks the interaction of α4β7 with its cognate ligands MAdCAM-1 and VCAM-1 with IC50values of 0.075 and 0.089 nM, respectively, and blocks the interaction between αEβ7 and its ligand E-cadherin with an IC50value of 3.96 nM[1].
体内研究
(In Vivo)

Etrolizumab (rhuMAb Beta7; 5 mg/kg; i.v.; once; normal female BALB/c mice) decreases β7 integrins on T lymphocytes[2].
Etrolizumab (200 μg (100 μL); i.p.; once) inhibits lymphocyte homing in the CD45RBhighT cell-reconstituted SCID mouse model of colitis[2].

Animal Model: Normal female BALB/c mice (17-21 g)[2]
Dosage: 5 mg/kg
Administration: Intravenous injection; once
Result: Had 98.3% of intraepithelial CD8+T-cell β7 integrin receptors and 90.0% of intraepithelial CD4+T-cell β7 integrin receptors after 24 h.
Animal Model: SCID mouse model of colitis[2]
Dosage: 200 μg (100 μL)
Administration: Intraperitoneal injection; once
Result: Blocked lymphocyte recruitment and homing to the inflamed colon.
Clinical Trial
性状

Liquid
CAS 号

1044758-60-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Baidu
map