您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> 3,6-DMAD hydrochloride
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
3,6-DMAD hydrochloride
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
3,6-DMAD hydrochloride图片
包装与价格：
包装 价格(元)
5mg 电议
10mg 电议
50mg 电议

半岛bd体育手机客户端 介绍
3,6-DMAD hydrochloride 是一种吖啶衍生物，是一种有效的 IRE1α-XBP1s通路抑制剂。 3,6-DMAD hydrochloride 通过 IRE1α-XBP1s 通路促进 IL-6 分泌。3,6-DMAD hydrochloride 可抑制 IRE1α 寡聚化和核糖核酸内切酶 (RNase) 活性。3,6-DMAD hydrochloride 可用于癌症的研究。
生物活性

3,6-DMAD hydrochloride, an acridine derivative, is a potentIRE1α-XBP1spathway inhibitor. 3,6-DMAD hydrochloride promotesIL-6secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research ofcancer[1][2].
体外研究
(In Vitro)

3,6-DMAD hydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines[1].
3,6-DMAD hydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner[1].
3,6-DMAD hydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity[1].
3,6-DMAD hydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation[1].

Cell Viability Assay[1]

Cell Line: RPMI 8226 and MM1.R human MM cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 6 μM
Incubation Time: 24 hours
Result: Inhibited cell survival rate in a dose dependent manner.

Western Blot Analysis[1]

Cell Line: HT1080 cells treated with Tg (0.3 μM)
Concentration: 0, 5, 10 and 30 μM
Incubation Time: 14 hours
Result: Showed XBP1s inhibition at as low as 0.5 μM.
体内研究
(In Vivo)

3,6-DMAD hydrochloride (10 mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo[1].
3,6-DMAD hydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo[1].

Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; three times every 12 hours, for 84 hours
Result: Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.
Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; every 48 hours, for 12 days
Result: Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.
性状

Solid
Formula

C22H31N5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:

DMSO : 25 mg/mL(Need ultrasonic)
Baidu
map