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SOP1812
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SOP1812图片
CAS NO: 2546091-70-5
包装与价格：
包装 价格(元)
10 mM * 1 mL in DMSO 电议
5mg 电议
10mg 电议
50mg 电议
100mg 电议

半岛bd体育手机客户端 介绍
SOP1812 是一种 naphthalene diimide (ND) 衍生物，具有抗肿瘤活性。SOP1812 能够与 quadruplex arrangements (G4s)结合，并下调多个癌症基因通路。SOP1812 对 hTERT G4 和 HuTel21 具有很强的亲和力，其 KD值分别为 4.9 和 28.4 nM。G4SOP1812 可用于癌症的研究。
生物活性

SOP1812 is a naphthalene diimide (ND) derivative with anti-tumor activity. SOP1812 binds toquadruplex arrangements (G4s), and down-regulates severalcancergene pathways. SOP1812 shows great affinity to hTERT G4 and HuTel21 G4 withKDvalues of 4.9 and 28.4 nM, respectively. SOP1812 can be used for the research ofcancer[1].
体外研究
(In Vitro)

SOP1812 (0-50 nM; 96 h) inhibits the proliferation of many cancer cells[1].
SOP1812 (0-800 nM; 6-24 h) shows great affinity to hTERT G4 and HuTel21 G4[1].
SOP1812 (40 nM; 6-24 h) affects Wnt/β-catenin, axon guidance, Hippo, MAPK and Rap1 pathways[1].

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cell lines
Concentration: 0-50 nM
Incubation Time: 96 hours
Result: Showed anti-proliferation ability to MIA PaCa-2, PANC-1, Capan-1 and BxPC-3 cells with GI50values of 1.3, 1.4, 5.9 and 2.6 nM, respectively.

Cell Viability Assay[1]

Cell Line: PANC-1 cells
Concentration: 0, 100, 400 and 800 nM
Incubation Time: 6 and 24 hours
Result: Binded to hTERT G4 and HuTel21 G4 withKDvalues of 4.9 and 28.4 nM, respectively.

Cell Viability Assay[1]

Cell Line: MIA PaCa-2 Cells
Concentration: 40 nM
Incubation Time: 6 and 24 hours
Result: Affected WNT5B, DVL1, AXIN and APC2 expression which includes in Wnt/β-catenin pathway and also showed effects on axon guidance, Hippo, MAPK, and Rap1 pathways.
体内研究
(In Vivo)

SOP1812 (1 mg/kg; i.v. once or twice per week for 28 days) shows anti-tumor activity in MIA PaCa-2 xenografts mice and KPC mice[1].

Animal Model: Female athymic nude mice with MIA PaCa-2 xenografts[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once or twice per week; for 28 days
Result: Showed complete tumor regression and no significant tumor regrowth after day 28 on several animals.
Animal Model: KPC mice with PDAC symptoms[1]
Dosage: 1 mg/kg
Administration: Intravenous injection; 1 mg/kg once per week; for 3 weeks
Result: Significantly extended survival of KPC mice and showed a better effect than gemcitabine.
分子量

791.98
性状

Solid
Formula

C45H57N7O6
CAS 号

2546091-70-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro:

DMSO : 200 mg/mL(252.53 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量 1 mg 5 mg 10 mg
1 mM 1.2627 mL 6.3133 mL 12.6266 mL
5 mM 0.2525 mL 1.2627 mL 2.5253 mL
10 mM 0.1263 mL 0.6313 mL 1.2627 mL
*

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。
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