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RIP1/RIP3/MLKL activator 1
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RIP1/RIP3/MLKL activator 1图片
CAS NO: 2682850-41-3
包装与价格：
包装 价格(元)
5mg 电议
10mg 电议
25mg 电议
50mg 电议
100mg 电议

半岛bd体育手机客户端 介绍
RIP1/RIP3/MLKL activator 1 (Compound 6i) 是一种有效的抗胶质瘤 ( anti-glioma) 药物。RIP1/RIP3/MLKL activator 1 通过激活 RIP1/RIP3/MLKL通路诱导细胞坏死 （ necroptosis）。 RIP1/RIP3/MLKL activator 1 可透过血脑屏障。
生物活性

RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potentanti-gliomaagent. RIP1/RIP3/MLKL activator 1 inducesnecroptosisthroughRIP1/RIP3/MLKLpathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability[1].
IC50& Target

RIP1, RIP3, MLKL[1]
体外研究
(In Vitro)

RIP1/RIP3/MLKL activator 1 (Compound 6i) (96 h) shows antiproliferative activities in human glioma cell lines[1].
RIP1/RIP3/MLKL activator 1 (0-4 μM, 0-72 h) exhibits remarkable antiproliferative activity for U251 cells in a time- and concentration-dependent manner[1].
RIP1/RIP3/MLKL activator 1 (10 μM, 0-72 h) shows acceptable stability[1].
RIP1/RIP3/MLKL activator 1 (0-2 μM, 24 h) effectively inhibits the migration of U251 cells[1].
RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway, and induces mitochondrial depolarization in U251 cells[1].
RIP1/RIP3/MLKL activator 1 could not induce apoptosis in U251 cells[1].

Cell Proliferation Assay[1]

Cell Line: A172, LN229, U87, U251 and L02 cell lines
Concentration: 0-4 μM for U251 cells
Incubation Time: 96 h; 24, 48, and 72 h for U251 cells
Result: Showed antiproliferative activity with IC50values of 3.03 ± 0.70, 1.78 ± 0.79, 1.22 ± 0.89, 0.94 ± 0.45, and 0.99 ± 0.46 μM against A172, LN229, U87, U251 and L02 cells, respectively. Time- and concentration-dependently inhibited the growth in U251 cells.

Western Blot Analysis[1]

Cell Line: U251
Concentration: 0, 0.5, 1, 2, and 4 μM
Incubation Time: 24 or 48 h
Result: Concentration-dependently upregulated the expression of p-RIP1, RIP1, p-RIP3, RIP3, p-MLKL, and MLKL at 24 or 48 h.
体内研究
(In Vivo)

RIP1/RIP3/MLKL activator 1 (Compound 6i) (2.50 ng/tail; i.v.; 48 h) inhibits U251 cell proliferation in vivo and exerts acceptable BBB permeability[1].

Animal Model: Zebrafish wide-type AB strain; 200 CM-DiI labeled U251 cells were transplanted into yolk sac of each wild-type zebrafish embryos at 2 dpf (2 days postfertilization)[1]
Dosage: 2.50 ng/tail
Administration: Microinjection; 48 h
Result: Remarkably reduced the U251 xenografts fluorescence intensity.
分子量

676.93
性状

Solid
Formula

C43H56N4O3
CAS 号

2682850-41-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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