CAS NO: | 1005264-47-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 |
MX69 is an inhibitor ofMDM2/XIAP, used forcancertreatment. |
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体外研究 (In Vitro) |
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1].
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体内研究 (In Vivo) |
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1].
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分子量 |
474.57 |
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性状 |
Solid |
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Formula |
C27H26N2O4S |
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CAS 号 |
1005264-47-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL(210.72 mM;Need ultrasonic) H2O :< 0.1 mg/mL(insoluble)
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In Vivo:
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