CAS NO: | 404950-80-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 |
Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selectiveHDACinhibitor, and has antineoplastic activities[1][2]. Panobinostat inducesHIV-1virusproduction even at low concentration range 8-31 nM, stimulatesHIV-1expression in latently infected cells[4]. Panobinostat induces cellapoptosisandautophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3]. |
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IC50& Target[1][5] |
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体外研究 (In Vitro) |
Panobinosta (LBH589) induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta treatment results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells[1]. Panobinostat exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50ranging from 5 to 100 nM[2].
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体内研究 (In Vivo) |
Panobinosta (10, 20 mg/kg, i.p.) significantly slows tumor growth derived from Meso and NSCLC cells in vivo models. Panobinosta markedly increases acetylation of histone H3 and H4 of H69 human SCLC cells harvest from SCID mice[2]. Panobinostat (5, 10 and 20 mg/kg i.p.) demonstrates a clear benefit of decreased tumor burden, significantly improves TTE and reduces bone density loss in a disseminated multiple myeloma mouse model[3].
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Clinical Trial |
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分子量 |
349.43 |
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性状 |
Solid |
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Formula |
C21H23N3O2 |
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CAS 号 |
404950-80-7 |
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中文名称 |
帕比司他 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 100 mg/mL(286.18 mM) *"≥" means soluble, but saturation unknown.
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In Vivo:
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