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As-358 hydrochloride
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
As-358 hydrochloride图片
CAS NO: 2374723-26-7
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
As-358 (hydrochloride) 对埃博拉病毒 ( Ebola virus) 和马尔堡病毒 ( Marburg virus) 具有抑制活性， IC50分别为 9.1 μM 和 18.1 μM，同时也具有良好的体内安全性。
生物活性

As-358 (hydrochloride) has inhibitory effects againstEbola virusandMarburg viruswithIC50s of 9.1 μM and 18.1 μM, as well as exhibits goodin vivosafety[1].
IC50& Target

IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1]
体外研究
(In Vitro)

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1].

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
体内研究
(In Vivo)

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1].

Animal Model: ICR mice[1]
Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg
Administration: IG; single (observed for 7 days)
Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50>1000 mg/kg.
分子量

329.91
Formula

C18H32ClNO2
CAS 号

2374723-26-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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