CAS NO: | 59865-13-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 |
Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibitsphosphataseactivity ofcalcineurinwith anIC50of 5 nM[3]. Cyclosporin A also inhibitsCD11a/CD18adhesion[8]. |
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IC50& Target |
IC50: 7 nM (calcineurin) |
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体外研究 (In Vitro) |
Cyclosporin A is able to bind with the cyclophilin in T cells[1]. Cyclosporin A works by forming a Cyclophilin-Cyclosporin A complex to inhibit calcineurin[2]. Cyclosporin A inhibits calcineurin in stimulated cells with an IC50value of 7 nM[3]. Cyclosporin A suppresses the nuclear translocation of NF-AT[4]. Cyclosporin A shows an effect on mitochondria via preventing the MTP from opening with an IC50of 39 nM[5].
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体内研究 (In Vivo) |
Cyclosporin A has immunosuppressive activity, and is active via parenteral and p.o. administration in mice, rat and guinea pigs[6]. Cyclosporin A can be used in organ transplantation to prevent rejection[7].
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Clinical Trial |
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分子量 |
1202.61 |
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性状 |
Solid |
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Formula |
C62H111N11O12 |
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CAS 号 |
59865-13-3 |
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中文名称 |
环孢霉素A;环孢素A;环孢多肽A;环孢灵;赛斯平;环孢素 |
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结构分类 |
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来源 |
the fungus Beauveria nivea. |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 62.5 mg/mL(51.97 mM;Need ultrasonic) Ethanol : 50 mg/mL(41.58 mM;Need ultrasonic)
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In Vivo:
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