NFAT inhibitor, Cell Permeable 是一种细胞可渗透的活化 T 细胞核因子 (NFAT) 抑制剂。
Cas No. |
592517-80-1 |
分子式 |
C147H259N67O36S |
分子量 |
3573.15 |
溶解度 |
Soluble in DMSO |
储存条件 |
Store at -20°C |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice. Cell permeable. Elloumi et al (2012) A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 7 e34172 PMID:22479554 |Noguchi et al (2004) A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 10 305 PMID:14770176 |